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sparsentan will lessen the extent or impact of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and reduces efficacy associated with these substrates.modafinil will lower the level or outcome of mavacamten by affecting hepatic/intestinal enzyme CY